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Osteoimmune Interactions in Inflammatory Bowel Disease: Central Role of Bone Marrow Th17 TNFα Cells in
Abdelilah Wakkach1, Matthieu Rouleau1, Claudine Blin-Wakkach1
1CNRS, UMR 7370, Laboratoire de PhysioMédecine Moléculaire (LP2M), Faculté de Médecine, Nice, France; University Nice Sophia Antipolis, Nice, France.
Abstract:
Osteoimmunology is an interdisciplinary research field dedicated to the study of the crosstalk between the immune and bone systems. CD4(+) T cells are central players in this crosstalk. There is an emerging understanding that CD4(+) T cells play an important role in the bone marrow (BM) under physiological and pathological conditions and modulate the differentiation of bone-resorbing osteoclasts. However, identification of the mechanisms that maintain CD4(+) T cells in the BM is still a matter of investigation. This article describes the CD4(+) T cell populations of the BM and reviews their role as osteoclastogenic population in inflammatory bowel disease.
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