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Updated: Mar 27, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Synthesis of Xenia diterpenoids and related metabolites isolated from marine organisms
Tatjana Huber1, Lara Weisheit1, Thomas Magauer1
1Department of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich, Butenandtstraße 5-13, 81377 Munich, Germany.
Abstract:
This review describes strategies for the chemical synthesis of xenicane diterpenoids and structurally related metabolites. Selected members from the four different subclasses of the Xenia diterpenoid family, the xenicins, xeniolides, xeniaphyllanes and xeniaethers, are presented. The synthetic strategies are discussed with an emphasis on the individual key reactions for the construction of the uncommon nine-membered carbocycle which is the characteristic structural feature of these natural products. Additionally, the putative biosynthetic pathway of xenicanes is illustrated.
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