Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
Related Experiment Video
Updated: Mar 27, 2026

Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
Camilla Matassini1, Stefania Mirabella1, Andrea Goti1
1Dipartimento di Chimica "Ugo Schiff", Università di Firenze, Via della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy.
Abstract:
The synthesis of new multivalent architectures based on a trihydroxypiperidine α-fucosidase inhibitor is reported herein. Tetravalent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne-catalyzed cycloaddition (CuAAC) between suitable scaffolds bearing terminal alkyne moieties and an azido-functionalized piperidine as the bioactive moiety. A preliminary biological investigation is also reported towards commercially available and human glycosidases.
Related Concept Videos
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Dipeptidyl Peptidase 4 Inhibitors
Drug Accumulation During Multiple Dosing: Repetitive IV Injections

