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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Rh Blood Group01:19

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Fetal Circulation01:14

Fetal Circulation

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Related Experiment Video

Updated: Mar 27, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
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Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

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Neonatal Hemophilia: A Rare Presentation.

Nuno Ferreira1, Elisa Proença1, Cristina Godinho1

  • 1Neonatal Intensive Care Unit , Portugal.

Pediatric Reports
|January 7, 2016
PubMed
Summary

Severe hemophilia A, a rare X-linked disorder, can manifest in newborns as subgaleal hemorrhage. Early diagnosis through coagulation studies is crucial for managing unexplained bleeding in infants.

Keywords:
Hemophilia Aextracranial bleedingneonatesubgaleal hemorrhage

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Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
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Area of Science:

  • Pediatric Hematology
  • Neonatal Medicine
  • Genetics

Background:

  • Hemophilia A is an X-linked genetic disorder characterized by deficient Factor VIII activity, increasing bleeding risk.
  • Neonatal diagnosis often follows postpartum bleeding or complications from medical procedures.
  • Subgaleal hemorrhage is a rare but severe neonatal extracranial bleed with high mortality, linked to trauma or coagulation issues.

Observation:

  • A neonate with no family history or pregnancy complications presented with severe subgaleal hemorrhage 52 hours after birth.
  • The infant underwent aggressive supportive care and bleeding management.
  • Unexpected bleeding prompted coagulation studies, revealing severe hemophilia A.

Findings:

  • Severe hemophilia A was diagnosed in a neonate presenting with subgaleal hemorrhage.
  • The condition was identified despite an unremarkable family history and uneventful delivery.
  • No sequelae were observed in the neonate following management.

Implications:

  • This case highlights a rare presentation of hemophilia A in the neonatal period.
  • It underscores the importance of coagulation studies in evaluating unexplained severe bleeding in newborns.
  • Early identification of hemophilia A is vital for preventing severe complications.