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Related Concept Videos

IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

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The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
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Insulin: Dosing Regimen and Adverse Effects01:16

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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
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One-Compartment Model: IV Infusion01:09

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Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
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Insulin Formulations: Types and Delivery01:27

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
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Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

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Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
334
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

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Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
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Improving IV Insulin Administration in a Community Hospital
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The Variable Rate Intravenous Insulin Infusion Protocol.

Benjamin Collard1, Jonathan Sturgeon1, Natasha Patel1

  • 1St Georges Healthcare NHS Trust.

BMJ Quality Improvement Reports
|January 7, 2016
PubMed
Summary

A standardized Variable Rate Intravenous Insulin Infusion (VRIII) protocol reduced medication errors and improved glucose control in hospitalized patients. Ongoing staff education is crucial for maintaining the protocol's effectiveness.

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Area of Science:

  • Clinical Pharmacy
  • Endocrinology
  • Patient Safety

Background:

  • High insulin use in inpatients is linked to frequent and severe medication errors.
  • Baseline audits revealed significant variability in intravenous insulin prescription practices, including fluid choice, electrolyte monitoring, and prescription clarity.
  • Existing practices led to inconsistent glycaemic management and potential patient harm.

Purpose of the Study:

  • To standardize intravenous insulin prescription for inpatients across the trust.
  • To evaluate the uptake and effectiveness of a new Variable Rate Intravenous Insulin Infusion (VRIII) protocol.
  • To reduce medication errors and improve glycaemic and electrolyte control.

Main Methods:

  • Implementation of a trust-wide Variable Rate Intravenous Insulin Infusion (VRIII) protocol.
  • Making the protocol accessible via the intranet and providing staff education.
  • Monitoring protocol uptake, medication errors, and patient glucose and electrolyte levels.

Main Results:

  • Successful routine use of the VRIII protocol throughout the trust.
  • Observed decrease in prescribing and administrative errors associated with insulin administration.
  • Demonstrated good glucose and electrolyte control in patients managed with the protocol.

Conclusions:

  • Standardized protocols, like the VRIII, effectively reduce medication errors in insulin prescribing.
  • The protocol ensures good glycaemic control and electrolyte balance.
  • Continuous education of clinical staff is essential for sustained protocol efficacy and patient safety.