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Updated: Mar 27, 2026
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
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Improving time to antibiotics and implementing the "Sepsis 6".
1NHS Lanarkshire, UK.
BMJ Quality Improvement Reports
|January 7, 2016
Summary
Implementing the "Sepsis 6" protocol within one hour significantly reduces patient mortality. A UK hospital
Area of Science:
- Critical Care Medicine
- Hospital Quality Improvement
- Infectious Disease Management
Background:
- Sepsis management requires timely intervention.
- The "Sepsis 6" protocol is a guideline for rapid sepsis care.
- Compliance with sepsis protocols impacts patient outcomes.
Purpose of the Study:
- To assess adherence to the "Sepsis 6" and time to first antibiotic (TTFA) in a UK hospital.
- To evaluate the effectiveness of a sepsis improvement plan.
- To reduce mortality associated with sepsis.
Main Methods:
- Retrospective audit of patient case notes for "septic patients" receiving intravenous antibiotics.
- Assessment of compliance with each "Sepsis 6" element and TTFA.
- Implementation of a sepsis improvement plan including education, multidisciplinary meetings, and a standardized proforma.
Main Results:
- The average time to first antibiotic (TTFA) decreased from 6 hours to 1.4 hours post-intervention.
- Enhanced compliance with most elements of the "Sepsis 6" was observed.
- Systematic process changes and education improved sepsis management.
Conclusions:
- An educational initiative and systematic process changes effectively reduced TTFA and improved "Sepsis 6" compliance.
- Continued assessment and process refinement are crucial for sustained improvement in sepsis care.
- Effective sepsis management protocols are vital for reducing patient mortality.
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