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Related Experiment Videos

Extracorporeal immunoadsorption with IM-PH or IM-TR column.

Z Yamazaki1, Y Idezuki, N Inoue

  • 12nd Department of Surgery, University of Tokyo, Japan.

Biomaterials, Artificial Cells, and Artificial Organs
|January 1, 1989
PubMed
Summary

New physicochemical immunoadsorbents overcome limitations of biological types for treating immune disorders. These novel materials offer a stable and accessible alternative for conditions like rheumatoid arthritis and multiple sclerosis.

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Alanine Racemase from an Acidophile, Acidiphilium organovorum: Purification and Characterization.

Bioscience, biotechnology, and biochemistry·2016

Area of Science:

  • Biomedical Engineering
  • Immunology
  • Materials Science

Background:

  • Biological affinity adsorbents (e.g., Prosorba) are used for immune disorders, alloimmunization, and cancer.
  • Challenges with biological adsorbents include raw material supply, handling, sterilization, and preservation.
  • Need for alternative immunoadsorbent technologies to overcome these limitations.

Purpose of the Study:

  • To develop novel physicochemical immunoadsorbents to address the supply and handling issues of biological adsorbents.
  • To evaluate the efficacy and selectivity of these new adsorbents for therapeutic applications.

Main Methods:

  • Development of IM-TR and IM-PH physicochemical immunoadsorbents using polyvinyl alcohol gel.
  • Tryptophan (IM-TR) and phenylalanine (IM-PH) were used as ligands.

Related Experiment Videos

  • Evaluation of adsorbent selectivity and efficiency, particularly for anti-acetylcholine receptor antibodies.

    • Main Results:

    • IM-PH demonstrated superior selectivity compared to IM-TR.
    • IM-TR showed higher efficiency in adsorbing anti-acetylcholine receptor antibody.
    • Successful clinical application of IM-PH plasma perfusion in patients with rheumatoid arthritis, systemic lupus erythematosus (SLE), and multiple sclerosis (MS).

    Conclusions:

    • Physicochemical immunoadsorbents (IM-TR, IM-PH) offer a viable alternative to biological adsorbents.
    • These novel adsorbents overcome challenges related to raw material availability and handling.
    • IM-PH shows promise for treating autoimmune diseases like rheumatoid arthritis, SLE, and MS.