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Functional profile of S100A4-deficient T cells
Kathleen Weatherly1, Marie Bettonville1, David Torres1
1Institute for Medical Immunology Université Libre de Bruxelles (ULB) Gosselies Belgium.
Immunity, Inflammation and Disease
|January 7, 2016
Summary
The protein S100A4, known for cancer cell invasion, is found in memory T cells. However, this study shows S100A4 is not essential for T cell migration or immune responses.
Area of Science:
- Immunology
- Cell Biology
Background:
- The protein S100A4 is recognized for its role in cancer cell motility and invasion.
- S100A4 expression has also been observed in T cells, suggesting a potential role in T cell function.
Purpose of the Study:
- To investigate the role of S100A4 in T cell motility and inflammation.
- To determine if S100A4 is essential for T cell migration and immune responses.
Main Methods:
- Utilized S100a4(+/Gfp) reporter mice to track S100A4 expression in T cells.
- Assessed in vitro migration of memory T cells towards the chemokine CXCL10.
- Evaluated T cell memory responses and the development of protective immunity and autoimmunity in S100A4-deficient mice.
Main Results:
- S100A4 is exclusively expressed in memory T cells (CD4+ and CD8+), particularly effector memory T cells.
- S100A4 was not required for in vitro migration of memory T cells.
- T cell memory responses, protective immunity, and inflammatory reactions were normal in S100A4-deficient mice.
Conclusions:
- S100A4 expression in T cells is limited to memory subsets.
- S100A4 is dispensable for T cell motility, migration, and inflammatory potential.
- The absence of S100A4 does not impair T cell-mediated immunity or autoimmunity development.
