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Delayed Diagnosis of Hypothyroidism in Children: Report of 3 Cases

Nosrat Ghaemi1, Sepideh Bagheri1, Saghi Elmi1

  • 1Department of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.

Iranian Red Crescent Medical Journal
|January 7, 2016
PubMed

Insights

Early diagnosis of pediatric hypothyroidism is crucial. This study highlights unusual presentations and emphasizes the need for thyroid function tests in children with growth issues to ensure timely treatment and improved outcomes.

Area of Science:

  • Pediatric Endocrinology
  • Endocrinology
  • Child Health

Background:

  • Hypothyroidism is a common endocrine disorder in children, often presenting with diverse signs and symptoms.
  • Diagnosis requires a high index of suspicion due to varied clinical manifestations.

Observation:

  • This report details three pediatric cases with atypical hypothyroidism presentations and delayed diagnoses.
  • Clinical manifestations included short stature, delayed bone age, hair loss, anemia, hypercholesterolemia, and persistent constipation leading to surgeries.
  • One child exhibited mental retardation and deafness, while the others had normal neurodevelopment.

Findings:

  • Laboratory results consistently showed decreased Thyroxin (T4) and elevated thyroid-stimulating hormone (TSH) levels.
  • Hormonal replacement therapy over one year led to improvements in growth parameters and hematological values.

Implications:

  • Thyroid hormonal evaluation is recommended for children with short stature, particularly those with delayed bone age.
  • Increased attention to pediatric growth monitoring is necessary for early detection and management of hypothyroidism.
Abstract

Keywords:
Bone AgeConstipationDeafnessHypothyroidismMental RetardationShort Stature

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