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[A survey on the constitutional status of perinates in China]
Insights
This study monitored over 1.2 million infants in China, finding a birth defect incidence of 130.1 per 10,000. Congenital malformations significantly contributed to perinatal deaths.
Area of Science:
- Perinatology
- Public Health
- Medical Genetics
Background:
- Birth defects represent a significant global health concern.
- Understanding the epidemiology of congenital anomalies is crucial for public health interventions.
- Previous data on the incidence and types of birth defects in China were limited.
Purpose of the Study:
- To determine the incidence of various birth defects in China.
- To identify the leading categories of major birth defects.
- To analyze the contribution of congenital malformations to perinatal mortality.
Main Methods:
- A 12-month prospective study (1986.10-1987.9) monitored 1,243,284 perinates in 945 hospitals across 29 Chinese provinces.
- Data collection included live and still births from 28 weeks gestation to 7 days postpartum.
- 101 categories of birth defects were recorded and analyzed.
Main Results:
- A total of 16,172 infants had birth defects, yielding an overall incidence of 130.1 per 10,000.
- The five most frequent major birth defects were anencephaly, hydrocephaly, spina bifida, cleft lip with cleft palate, and congenital heart diseases.
- Congenital malformations accounted for 17.8% of 33,137 perinatal deaths, with a perinatal mortality rate of 26.7 per 10,000.
Conclusions:
- Birth defects pose a substantial burden in China, with specific anomalies being most prevalent.
- Congenital malformations are a major contributor to perinatal mortality.
- Further research and targeted interventions are needed to address the impact of birth defects.
Abstract:
Data of all categories of birth defects among live and still births from 28 weeks of gestation to a period within 7 days after delivery were collected. During a period of 12 months (1986.10-1987.9), there were 1,243,284 perinates monitored in 945 hospitals of 29 provinces, cities and autonomous regions. Among these, 16,172 perinates were with birth defects. Altogether, 101 categories of birth defects were noted. The total incidence of the 101 categories of birth defects in China was 130.1 per 10,000. The 5 leading categories of major birth defects by frequency were: anencephaly, hydrocephaly, spina bifida, cleft lip with cleft palate, and congenital heart diseases. Perinatal deaths totaled 33,137 and the perinatal mortality was 26.7 per 10,000. Among the causes of perinatal death, congenital malformation accounted for 17.8%. There were 44,469 births (35.8%) of full-term low birth weight infants, and 1,748 of them were with birth defects. The incidence of birth defects in full-term low birth weight infants was 393.1 per 10,000.