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Ethanol metabolism, toxicity and genetic polymorphism

K Iwahashi1, H Suwaki1

  • 1Department of Neuropsychiatry, Kagawa Medical School, Kida-gun, Miki-cho, Kagawa 761-07Department of Physiology, Azabu University, Sagamihara-city, Fuchinobe 1-17-71, Kanagawa, 229, Japan.

Addiction Biology
|January 7, 2016
PubMed
Summary

Genetic variations in alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) influence alcohol metabolism and toxicity. ALDH2 deficiency, common in East Asians, causes flushing and reduces alcohol dependence risk.

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