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Chenopodium ambrosioides L. extract prevents bone loss
Ciro Dantas Soares1, Maria Goretti Freire de Carvalho2, Rejane Andrade de Carvalho3
1Department of Dentistry, Universidade Potiguar, Natal, RN, Brazil.
Acta Cirurgica Brasileira
|January 7, 2016
Summary
Chenopodium ambrosioides L (mastruz) extract showed potential in preventing bone loss and altering bone metabolism in ovariectomized rats. This study suggests mastruz may positively impact bone health by influencing blood markers and bone marrow composition.
Area of Science:
- Pharmacology
- Bone Biology
- Animal Models
Background:
- Osteoporosis is a significant health concern, often induced in animal models via ovariectomy.
- Bone metabolism is complex, involving cellular changes and biochemical markers.
- Chenopodium ambrosioides L (mastruz) is a plant with traditional uses, prompting scientific investigation into its medicinal properties.
Purpose of the Study:
- To investigate the efficacy of Chenopodium ambrosioides L (mastruz) extract in preventing bone loss.
- To evaluate the impact of mastruz extract on bone metabolism in an ovariectomized rat model.
- To assess the effects of mastruz on biochemical and histological parameters related to bone health.
Main Methods:
- Ovariectomy was performed on twelve rats to induce osteoporosis.
- Rats were divided into control and mastruz extract treatment groups for 30 days.
- Blood, tibia, and liver samples were analyzed for biochemical, histological, and histomorphometric changes.
Main Results:
- The mastruz group exhibited significantly larger cortical bone dimensions compared to the control group.
- The control group showed a higher proportion of adipocytes in the bone marrow.
- Significant alterations in blood levels of liver enzymes, lipids, proteins, and lactate dehydrogenase were observed in the mastruz group.
Conclusions:
- The hydroalcoholic extract of mastruz influences bone metabolism.
- Mastruz extract demonstrated a protective effect against bone loss and adipocyte accumulation in bone marrow.
- Changes in blood proteins and enzymes indicate a broader systemic effect of mastruz on bone health.
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