Platelet monoamine oxidase (MAO) activity and alcoholism: is there a genuine association?

Monoamine oxidase (MAO) is a particle-bound flavoenzyme principally located in the outer mitochondrial membrane, which catalyzes the oxidative deamination of a variety of the amine transmitters in the central nervous system. There have been many reports from different groups around the world over the last 20 years that indicated a lower platelet MAO activity was associated with alcoholism. As there are multiple influences upon measured MAO activity, this article attempts to address each of the issues in turn for potential confounding of the reported association. These issues include: the duration of abstinence from alcohol, the substrate used for analysis, gender issues, association with different subtypes of alcoholics, the influence of other psychopathology, personality traits of alcoholics, the question of smoking, and proposed modes of transmission of MAO activity. The initial promise about MAO activity being a possible marker for alcoholism or a least a genetically predisposed subgroup has receded as the number of negative typology-based studies increases. The failure to account for a major confounding variable, e.g. smoking and other minor but possibly vital confounds in almost all these studies leaves the whole hypothesis open to criticism. However, the possible association between personality traits that might predispose to some if not all substances of addiction to low MAO activity may make it possible to reframe the hypothesized association in the setting of a generalized predisposition to addictions in particular, and to psychopathology in general. Nonetheless the association remains of great interest and may yet yield vital genetic and clinical information.