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Glucose kinetics in haemorrhagic hyperglycemia
O Ljungqvist1, E Sandberg, G Nylander
1Department of Surgery, Karolinska Hospital and Institute, Stockholm, Sweden.
Circulatory Shock
|August 1, 1989
Summary
Hemorrhagic hyperglycemia, a condition following blood loss, causes insulin resistance in rats. This study reveals that impaired glucose uptake contributes to elevated blood sugar levels after hemorrhage.
Area of Science:
- Physiology
- Endocrinology
Background:
- Hemorrhagic hyperglycemia is known to affect fluid homeostasis.
- In vitro studies suggest insulin resistance occurs after hemorrhage.
Purpose of the Study:
- To investigate the in vivo relationship between insulin, glucagon, adrenalin levels, and glucose disappearance rate (Rd) during hemorrhagic hyperglycemia.
- To determine the role of insulin resistance in hyperglycemia following experimental hemorrhage in rats.
Main Methods:
- Determined glucose disappearance rate (Rd) using 3-3H-glucose injection in control rats, rats with induced hemorrhage, and rats receiving glucose infusion.
- Measured peripheral insulin, glucagon, and adrenalin levels.
Main Results:
- Hyperglycemia levels were significantly elevated in both hemorrhage (22.9 +/- 1.9 mmol/L) and glucose infusion (20.4 +/- 1.4 mmol/L) groups compared to controls.
- Glucose disappearance rate (Rd) was significantly reduced after hemorrhage (9.7 +/- 0.4 mmol/100g/min) compared to controls (8.2 +/- 0.5 mmol/100g/min) and glucose infusion (34.1 +/- 0.6 mmol/100g/min).
- Both hemorrhage and glucose infusion treatments led to a greater than 200% increase in insulin levels.
Conclusions:
- Experimental hemorrhage in rats induces hyperglycemia.
- Insulin resistance plays a significant role in the development of hyperglycemia observed after hemorrhage.
- The study highlights the complex interplay between hemorrhage, insulin response, and glucose metabolism.