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Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications.

Xiang Wu1, Yuanwei Zhang, Kendra Takle

  • 1State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian, 116012, People's Republic of China.

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|January 7, 2016
PubMed
Summary
This summary is machine-generated.

Dye-sensitized core/shell upconversion nanoparticles (UCNPs) with ytterbium ion doping show enhanced luminescence. These nanoparticles enable deep-tissue optogenetics and in vivo imaging, improving biomedical applications.

Keywords:
bioimagingcore/active shell structuredye-sensitizingnear-infraredoptogeneticsupconversion nanoparticles

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Upconversion nanoparticles (UCNPs) offer unique optical properties but often require enhancement for broader applications.
  • Dye-sensitization and core/shell structures are known strategies to improve UCNP performance.

Purpose of the Study:

  • To enhance upconversion luminescence in dye-sensitized UCNPs by incorporating ytterbium ions (Yb3+) into the shell.
  • To synergistically combine dye-sensitization and core/shell enhancement for amplified upconversion efficiency.
  • To demonstrate the utility of these enhanced UCNPs in biomedical applications, including optogenetics and in vivo imaging.

Main Methods:

  • Synthesized dye-sensitized core/active shell UCNPs doped with Yb3+ in the shell.
  • Investigated energy transfer mechanisms from dye sensitizers to the UCNP core.
  • Developed UCNP-polymer composite systems for optogenetic applications.
  • Water-solubilized UCNPs using Pluronic F127 for biological imaging.

Main Results:

  • Achieved significantly enhanced upconversion luminescence through Yb3+ doping in the UCNP shell.
  • Demonstrated efficient energy transfer from the dye sensitizer to the UCNP core.
  • Successfully shifted the optogenetic neuron excitation window to 800 nm using UCNP-polymer implants.
  • Showcased high upconversion efficiency and successful in vivo imaging in a mouse model with water-solubilized UCNPs.

Conclusions:

  • Dye-sensitized core/active shell UCNPs with Yb3+ doping represent a powerful platform for boosting upconversion efficiency.
  • These enhanced UCNPs are suitable for advanced biomedical applications requiring deep tissue penetration and specific excitation wavelengths.
  • The developed UCNPs offer promising potential for in vivo imaging and optogenetic manipulation.