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Basilar dolichoectasia and the spontaneous intradural vertebral artery dissection

Hidetoshi Matsukawa1, Masaki Shinoda1, Motoharu Fujii1

  • 1a Department of Neurosurgery .

Brain Injury
|January 7, 2016
PubMed

Insights

Basilar dolichoectasia (BD) is associated with spontaneous intradural vertebral artery dissection (siVAD). This finding suggests a potential shared etiology between these vascular conditions, warranting further investigation.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Basilar dolichoectasia (BD) involves basilar artery elongation and dilation, often linked to atherosclerosis.
  • Spontaneous intradural vertebral artery dissection (siVAD) is a significant cause of stroke in younger populations.
  • The potential shared etiologies between BD and siVAD remain largely unexplored.

Purpose of the Study:

  • To investigate the relationship between basilar dolichoectasia (BD) and spontaneous intradural vertebral artery dissection (siVAD).
  • To compare clinical and radiological characteristics of patients with siVAD and controls.

Main Methods:

  • A case-control study involving 93 patients with siVAD and 93 controls.
  • Radiological definitions for ectasia (>4.5mm diameter) and dolichosis (abnormal bifurcation position) were used to identify BD.
  • Multivariate logistic regression analysis was employed to assess associations.

Main Results:

  • Patients with siVAD exhibited a higher prevalence of hypertension (OR=2.4, p=0.007).
  • A significant association was found between siVAD and basilar dolichoectasia (BD) (OR=3.7, p=0.036).

Conclusions:

  • The study suggests a relationship between basilar dolichoectasia (BD) and spontaneous intradural vertebral artery dissection (siVAD).
  • Further multi-institutional randomized studies with larger sample sizes are recommended to strengthen the evidence for this association.
Abstract

Keywords:
Dissectionmorphologyrisk factorvertebrobasilar disease

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