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An implantable wireless optogenetic stimulation system for peripheral nerve control.

Kang-Il Song, Sunghee E Park, Myoung-Soo Kim

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 7, 2016
    PubMed
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    This study presents an implantable wireless optogenetic system for peripheral nerve control. The system successfully elicited ankle movement wirelessly in mice using an LED optical cuff electrode.

    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Optogenetics

    Background:

    • Peripheral nerve control is crucial for restoring function after injury.
    • Optogenetics offers precise neural stimulation but often requires invasive wired systems.
    • Developing wireless, implantable systems is key for practical applications.

    Purpose of the Study:

    • To develop and evaluate an implantable wireless optogenetic stimulation system for peripheral nerve control.
    • To demonstrate the feasibility of wirelessly controlling nerve activity and inducing movement.

    Main Methods:

    • Designed an implantable system with an LED-based optical cuff electrode made of polydimethylsiloxane (PDMS).
    • Integrated a battery, optical stimulation controller, and a wireless communication system compliant with MICS regulations.

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  • Implanted the optical cuff electrode on the sciatic nerve of optogenetic transgenic mice (Thy1::ChR2) for stimulation.

    • Main Results:

    • Successfully elicited ankle movement in mice through wireless optical stimulation of the sciatic nerve.
    • Demonstrated that specific optical stimulation pulse parameters can generate movement.
    • The PDMS cuff electrode effectively illuminated the entire sciatic nerve.

    Conclusions:

    • The developed implantable wireless optogenetic system is effective for peripheral nerve control.
    • Wireless control of neural activity and induced movement is achievable.
    • This technology holds promise for future therapeutic applications in neural prosthetics.