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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
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Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

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Non-invasive quantification of brain [¹⁸F]-FDG uptake by combining medical health records and dynamic PET imaging

Elisa Roccia, Arthur Mikhno, Francesca Zanderigo

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 7, 2016
    PubMed

    Abstract:

    Quantification of regional cerebral metabolic rate of glucose (rCMRglu) via positron emission tomography (PET) imaging requires measuring the arterial input function (AIF) via invasive arterial blood sampling. In this study we describe a non-invasive approach, the non-invasive simultaneous estimation (nSIME), for the estimation of rCMRglu that considers a pharmacokinetic input function model and constraints derived from machine learning applied to a fusion of individual medical health records and dynamic [(18)F]-FDG-PET brain images data. The results obtained with our data indicate potential for future clinical application of nSIME, with correlation measures of 0.87 for rCMRglu compared to quantification with full arterial blood sampling.

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