Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell allocation and lineage in the early mouse embryo.

R L Gardner1

  • 1Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK.

Ciba Foundation Symposium
|January 1, 1989
PubMed
Summary

Early embryo development involves asymmetric cell contacts that polarize blastomeres, creating distinct cell populations. These populations may further differentiate into key embryonic tissues based on their position and history.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The timing of monozygotic twinning: a pro-life challenge to conventional scientific wisdom.

Reproductive biomedicine online·2014
Same author

The axis of polarity of the mouse blastocyst is specified before blastulation and independently of the zona pellucida.

Human reproduction (Oxford, England)·2006
Same author

Weaknesses in the case against prepatterning in the mouse.

Reproductive biomedicine online·2006
Same author

An investigation of the origin and significance of bilateral symmetry of the pronuclear zygote in the mouse.

Human reproduction (Oxford, England)·2005
Same author

Epigenesis versus preformation during mammalian development. Introduction.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2003
Same author

Is the plane of first cleavage related to the point of sperm entry in the mouse?

Reproductive biomedicine online·2003

Area of Science:

  • Developmental biology
  • Cell biology
  • Embryology

Background:

  • Early mammalian embryos exhibit asymmetric cell contacts.
  • Blastomere polarization is induced by these contacts and can persist through cell division.
  • This process generates distinct inner and outer cell populations.

Purpose of the Study:

  • To explore how initial cell polarization influences blastomere fate.
  • To investigate the role of microenvironmental differences in cell diversification.
  • To understand the mechanisms generating primitive endoderm/ectoderm and trophectoderm/inner cell mass.

Main Methods:

  • Observational studies of early mammalian embryo development.
  • Analysis of cell-cell interactions and their impact on blastomere fate.
  • Investigating the role of positional cues and cell history in differentiation.

Main Results:

  • Asymmetric cell contacts induce blastomere polarization, leading to inner and outer cell populations.
  • Distinct microenvironments contribute to the divergence of these cell populations.
  • This process is implicated in the formation of primitive endoderm/ectoderm and trophectoderm/inner cell mass.

Conclusions:

  • Cellular responses to positional cues change based on prior history or cell cycle.
  • Initial polarization and subsequent microenvironmental interactions drive early embryonic tissue formation.
  • Further cellular diversification occurs through specific interactions between established primary tissues.

Related Experiment Videos