Papillary carcinoma of prostatic ductal origin: a cytologic case report with immunohistochemical and quantitative DNA...

This report describes the aspiration biopsy cytology (ABC) of a case of papillary carcinoma of ductal origin, an uncommon malignant tumor of the prostate. Only one case has been previously reported in the cytology literature. Atypical papillary fragments are the distinctive cytologic findings. Similar to well-differentiated acinar carcinoma of the prostate, the cytologic features of malignancy in this lesion may be subtle, and diagnosis is based on the presence of the cytologic pattern. Positive immunohistochemical staining with prostate-specific acid phosphatase confirms the prostatic origin. Application is made of quantitative DNA analysis for prognostic determination.