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Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
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Lung assist devices influence cardio-energetic parameters: Numerical simulation study.

C De Lazzari, B Quatember, W Recheis

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
    |January 7, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Mechanical ventilators (MVs) and thoracic artificial lungs (TALs) impact cardiovascular function. Simulations show MVs decrease cardiac output and efficiency, while TAL configurations affect ventricular work and performance.

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    Area of Science:

    • Cardiovascular Physiology
    • Biomedical Engineering
    • Respiratory Mechanics

    Background:

    • Mechanical ventilators (MVs) and thoracic artificial lungs (TALs) are critical in managing respiratory failure.
    • Understanding their impact on the cardiovascular system is essential for optimizing patient care.

    Purpose of the Study:

    • To analyze the effects of MVs and TALs on cardiovascular parameters.
    • To evaluate left and right ventricular external work (EW), pressure-volume area (PVA), and cardiac mechanical efficiency (CME).

    Main Methods:

    • Utilized the CARDIOSIM(©) software simulator for comprehensive analysis.
    • Conducted simulation studies for patients undergoing MV without TAL.
    • Performed simulations for patients with TAL but without MV, exploring various configurations (in series, parallel, hybrid).

    Main Results:

    • MV (without TAL) simulations showed decreased ventricular EW, PVA, and cardiac output (CO) with increasing intrathoracic pressure.
    • Left ventricular CME increased, while right ventricular CME decreased under MV.
    • TAL simulations indicated reduced left ventricular EW/PVA in 'in series' configuration and optimal CO with 'in parallel' configuration.

    Conclusions:

    • Both MVs and TALs significantly influence cardiovascular hemodynamics.
    • TAL configuration critically impacts ventricular performance and CO, with 'in parallel' arrangements showing the most promise for CO optimization.