Real-time biochemical sensor based on Raman scattering with CMOS contact imaging

Area of Science:

• Biochemistry
• Optical Engineering
• Sensor Technology

Background:

• Quantitative biochemical concentration detection is crucial in chemical, biomedical, and environmental analysis.
• Existing methods often rely on expensive and complex instrumentation, limiting accessibility.

Purpose of the Study:

• To develop and present a novel biochemical sensor utilizing Raman scattering and CMOS contact imaging.
• To enable cost-effective and instant detection of solution concentrations.

Main Methods:

• The sensor integrates a laser diode, optical filter, sample holder, and a commercial CMOS sensor.
• Image processing software analyzes the Raman scattering output for quantitative measurements.

Main Results:

• The system achieves instant measurements with a resolution between 0.2 and 0.4 Mol.
• Performance is comparable to high-cost commercial spectrometers.

Conclusions:

• The developed sensor offers a low-cost, user-friendly, and small-scale solution for biochemical concentration detection.
• This technology has significant potential for application in diverse laboratory settings.