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Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

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The connection between MCI and Alzheimer disease: neurocognitive clues

Kübra Batum, Nilgün Çinar, Sevki Sahin

    Turkish Journal of Medical Sciences
    |January 8, 2016
    PubMed
    Abstract

    Insights

    Mild cognitive impairment (MCI) shows deficits in attention and memory compared to age-related cognitive decline. Further decline in personal information and executive functions may indicate early Alzheimer

    Area of Science:

    • Neurology
    • Gerontology
    • Cognitive Science

    Background:

    • Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia.
    • Distinguishing MCI from age-related cognitive decline (ARCD) and early Alzheimer's disease (AD) is crucial for timely intervention.

    Purpose of the Study:

    • To compare cognitive profiles of MCI, early AD, and ARCD.
    • To identify key differences that aid in the differential diagnosis of these conditions.

    Main Methods:

    • Retrospective analysis of patients meeting MCI, ARCD, or early AD criteria.
    • Assessment using Wechsler memory scale, executive function, visuospatial, language, and memory tests.
    • Inclusion of Mini-Mental State Examination, Geriatric Depression Scale, and Activities of Daily Living scales.

    Main Results:

    • MCI patients exhibited greater impairment in complex attention and long-term memory compared to ARCD.
    • No significant differences in activities of daily living were observed between MCI and ARCD.
    • Alzheimer's disease patients showed more pronounced memory and executive function deficits than MCI patients.

    Conclusions:

    • Impairments in orientation, complex attention, and long-term memory during ARCD follow-up may indicate MCI.
    • Progression of MCI with affected personal information and executive functions warrants consideration for early Alzheimer's disease.

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