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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
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Commensal bacteria modulate the tumor microenvironment.

Theofilos Poutahidis1, Susan E Erdman2

  • 1Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece 54124.

Cancer Letters
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Summary
This summary is machine-generated.

Gut microbes influence immune and hormonal factors, affecting preneoplastic lesions. This suggests the tumor microenvironment interacts with microbial-immune networks for potential holobiont engineering therapies.

Keywords:
CarcinogenesisCommensalMicrobesTumor macroenvironmentTumor microenvironment

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Area of Science:

  • Microbiology
  • Immunology
  • Oncology

Background:

  • Gut microbes significantly influence host physiology.
  • Microbial metabolites and immune signaling impact distant tissues.
  • Emerging evidence links gut microbiota to cancer development and progression.

Purpose of the Study:

  • To explore the interaction between the tumor microenvironment and systemic microbial-immune networks.
  • To investigate how gut microbes modulate factors affecting preneoplastic lesions.
  • To identify novel therapeutic strategies based on holobiont engineering.

Main Methods:

  • Review of recent findings on gut microbiome-host interactions.
  • Analysis of immune and hormonal pathways modulated by gut microbes.
  • Conceptual framework for understanding tumor microenvironment-microbiome interplay.

Main Results:

  • Gut microbes modulate systemic immune and hormonal factors.
  • These modulations impact the progression of preneoplastic lesions.
  • A potential interaction exists between tumor microenvironments and systemic microbial networks.

Conclusions:

  • Gut microbiota play a crucial role in cancer pathogenesis.
  • The tumor microenvironment is influenced by systemic microbial-immune interactions.
  • Holobiont engineering presents a promising therapeutic avenue for cancer treatment.