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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
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Reusable nanoengineered surfaces for bacterial recruitment and decontamination
Linnea K Ista1, Qian Yu2, Anand Parthasarathy3
1Center for Biomedical Engineering and the Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, New Mexico 87131l.
Biointerphases
|January 8, 2016
Summary
New materials combine fouling resistance and biocidal properties to combat biofouling. These surfaces capture, kill, and release microbes and debris, offering a promising solution for public health and industry.
Area of Science:
- Materials Science
- Biotechnology
- Surface Chemistry
Background:
- Biofouling poses significant challenges to public health and industry.
- Existing fouling-resistant and biocidal materials have limitations in long-term efficacy.
- Combined approaches offer enhanced solutions for biofouling control.
Purpose of the Study:
- To develop and evaluate a novel material combining fouling release and biocidal properties.
- To investigate the mechanism of antimicrobial activity and debris removal.
- To assess the cyclic performance of the developed material.
Main Methods:
- Utilized interference lithography to create nanopatterned initiators.
- Initiated atom transfer radical polymerization of poly(N-isopropylacrylamide) (PNIPAAm) for fouling release.
- Employed layer-by-layer deposition of poly(phenylene ethynylenes) for biocidal activity.
Main Results:
- Demonstrated dark-regime biocidal activity against Gram-positive and Gram-negative bacteria via ionic disruption.
- Observed effective removal of bacteria and debris upon temperature-induced PNIPAAm phase transition.
- Confirmed capture, killing, and release capabilities over multiple cycles.
Conclusions:
- The developed material effectively combats biofouling through a multi-modal approach.
- The combination of fouling release and biocidal properties offers a promising strategy for durable biofouling mitigation.
- This technology has potential applications in various industrial and public health sectors.
