Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

6.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

699
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
699
Antifungal Agents01:15

Antifungal Agents

37
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
37
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

2.1K
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
2.1K
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

2.0K
Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
2.0K
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

19
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
19

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-infective therapy and novel treatment options for coccidioidomycosis.

Expert review of anti-infective therapy·2026
Same author

Exhausted T cell phenotypes in disseminated coccidioidomycosis.

JCI insight·2026
Same author

Frequency and Duration of Diagnostic Delays Associated with Coccidioidomycosis and Risk Factors for Missed Diagnoses, United States.

Emerging infectious diseases·2026
Same author

<i>Pneumocystis jirovecii</i> Pneumonia in Non-HIV, Non-HCT Adults: Real-World Patterns of Overlapping Immunosuppression and PJP-Active Therapy.

The Annals of pharmacotherapy·2026
Same author

Fosmanogepix treatment for coccidioidomycosis under an expanded access program.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Closing the gap on antifungal resistance.

Nature medicine·2026
Same journal

Prevention and Control of Clostridioides difficile Infection for the Infectious Diseases Clinician.

Infectious disease clinics of North America·2026
Same journal

Infection Control Strategies to Prevent Emergence and Transmission of Resistant Gram-Negative Bacteria.

Infectious disease clinics of North America·2026
Same journal

Preventing the Spread of Tuberculosis in Health Care Settings.

Infectious disease clinics of North America·2026
Same journal

Threats to Success: Principles of Infection Prevention and Control in Health Care Settings, Part 2: Device and Pathogen Management.

Infectious disease clinics of North America·2026
Same journal

Ventilator-Associated Events: Surveillance and Prevention.

Infectious disease clinics of North America·2026
Same journal

Nosocomial Fungal Infections: Epidemiology, Control Strategies, and Prevention of Candida and Other Yeasts.

Infectious disease clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Mar 27, 2026

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K

Coccidioidomycosis.

Nathan W Stockamp1, George R Thompson2

  • 1Division of Infectious Disease, Department of Internal Medicine, University of California, San Francisco, Fresno, San Francisco, CA, USA.

Infectious Disease Clinics of North America
|January 8, 2016
PubMed
Summary
This summary is machine-generated.

Coccidioidomycosis, caused by Coccidioides fungi, requires careful antifungal therapy assessment. Current treatments offer infrequent cures for disseminated infections, necessitating reviews of management guidelines and newer agents.

Keywords:
CoccidioidesCoccidioidomycosisEpidemiologyMeningitisPrimary infectionTreatment

More Related Videos

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

7.5K
Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection
05:31

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection

Published on: September 14, 2019

10.4K

Related Experiment Videos

Last Updated: Mar 27, 2026

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
06:39

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

1.6K
Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

7.5K
Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection
05:31

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection

Published on: September 14, 2019

10.4K

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Coccidioides immitis and C posadasii cause coccidioidomycosis.
  • Infections are prevalent in the Southwestern US, Central, and South America.
  • Antifungal therapy is crucial, requiring periodic assessment.

Purpose of the Study:

  • To summarize coccidioidomycosis management guidelines.
  • To review data on challenging cases and newer antifungal agents.
  • To inform clinical decision-making for coccidioidomycosis treatment.

Main Methods:

  • Literature review of coccidioidomycosis management.
  • Analysis of factors influencing treatment decisions.
  • Review of clinical data for newer antifungal agents.

Main Results:

  • Treatment decisions depend on infection severity, duration, radiographic findings, titers, immunosuppression, and comorbidities.
  • Cure rates for disseminated coccidioidomycosis are low with current regimens.
  • Emerging data on newer agents for challenging cases are presented.

Conclusions:

  • Effective management of coccidioidomycosis involves tailored antifungal therapy.
  • Further research into novel agents is needed for disseminated infections.
  • Adherence to updated guidelines can improve patient outcomes.