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Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems
Gautier M A Ndong Ntoutoume1, Robert Granet1, Jean Pierre Mbakidi1
1Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
Abstract:
The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.
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