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Women in their late reproductive stage report more bladder symptoms like nocturia and incontinence than those in menopause transition. These symptoms are linked to reproductive stage, BMI, and race.

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Area of Science:

  • Urology
  • Women's Health
  • Reproductive Endocrinology

Background:

  • Bladder symptoms are prevalent in women, impacting quality of life and healthcare utilization.
  • Existing literature suggests a link between bladder symptoms, age, and menopause, though this is debated.
  • Midlife women experience various physiological changes impacting lower urinary tract function.

Purpose of the Study:

  • To investigate factors associated with bladder symptoms in midlife women.
  • To compare the prevalence of bladder symptoms between women in the late reproductive stage and those in menopause transition.

Main Methods:

  • Cross-sectional analysis of prospective cohort data from 158 midlife women (ages 44-54).
  • Data collection included anthropometrics, menstrual cycle data, follicle-stimulating hormone levels, and self-reported health and depressive symptoms.
  • Statistical analyses comprised descriptive statistics, group comparisons, and regression models.

Main Results:

  • Nocturia (72%) and urinary incontinence (50%) were common bladder symptoms.
  • Incontinence was less prevalent in African American women compared to European American and Latina women (p=0.001).
  • Urinary incontinence was more prevalent in the late reproductive stage than in menopause transition (p=0.024).
  • Women in the late reproductive stage were more likely to report nocturia than those in menopause transition, even after controlling for age.
  • Reproductive stage (p=0.016), higher body mass index (p=0.007), and race (p=0.017) significantly contributed to the variance in nighttime urinary frequency.

Conclusions:

  • Bladder symptoms, including nocturia and incontinence, are significantly associated with reproductive stage.
  • Women in the late reproductive stage experience higher rates of nocturia and incontinence compared to women in menopause transition.
  • Further research should explore the role of pelvic organ prolapse and structural differences in explaining these findings.