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Related Concept Videos

Probiotics01:22

Probiotics

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Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Development of Human Microbiota01:30

Development of Human Microbiota

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The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
21
Aging01:26

Aging

1.0K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

802
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
802
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

315
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
315

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Related Experiment Video

Updated: Mar 27, 2026

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
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Anti-Aging Effects of Probiotics.

Divya Sharma, Mary-Margaret Kober, Whitney P Bowe

    Journal of Drugs in Dermatology : JDD
    |January 8, 2016
    PubMed
    Summary

    Probiotics offer significant benefits for skin health, effectively combating aging signs. These beneficial microbes help restore skin pH, reduce oxidative stress, and improve barrier function for healthier skin and hair.

    Area of Science:

    • Dermatology and microbiology, focusing on the skin microbiome.

    Background:

    • Growing evidence supports probiotics' positive impact on skin health.
    • Probiotics influence skin at molecular, animal model, and human clinical trial levels.

    Purpose of the Study:

    • To review the literature on the beneficial effects of probiotics on skin aging.
    • To highlight the molecular mechanisms and clinical outcomes of probiotic use for skin health.

    Main Methods:

    • Literature review of studies on probiotics and skin.
    • Analysis of molecular, animal, and human clinical trial data.

    Main Results:

    • Probiotics restore acidic skin pH.
    • Probiotics alleviate oxidative stress and attenuate photoaging.
    • Probiotics improve skin barrier function and enhance hair quality.

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    Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
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    Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
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    Conclusions:

    • Probiotics play a role in slowing intrinsic and extrinsic skin aging.
    • The reviewed evidence supports probiotics as a viable strategy for skin rejuvenation and health.