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Metachronous small bowel metastasis from a mixed Müllerian mesodermal tumour
J M L Williamson1, M Stevens1, D Mahon1
1Taunton and Somerset NHS Foundation Trust , UK.
Annals of the Royal College of Surgeons of England
|January 8, 2016
Summary
Mixed Müllerian mesodermal tumors (MMMT) rarely metastasize to the small intestine. This report details a successful surgical resection of metachronous small bowel MMMT, a highly unusual presentation.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Mixed Müllerian mesodermal tumors (MMMT) are rare, aggressive carcinosarcomas.
- Metastatic progression of MMMT is uncommon, typically occurring via hematological, lymphatic, or intraperitoneal routes.
Observation:
- Intraperitoneal spread is the most frequent metastatic pathway for MMMT.
- The small intestine is rarely involved in MMMT progression, with only one prior case of synchronous involvement documented.
- This case presents a rare instance of metachronous MMMT involvement of the small bowel.
Findings:
- The patient presented with symptoms of subacute small bowel obstruction.
- Surgical exploration revealed MMMT involvement of the small intestine.
- The affected small bowel segment was successfully resected.
Implications:
- This case highlights the possibility of metachronous small bowel metastasis in MMMT.
- It underscores the importance of considering rare metastatic sites in the differential diagnosis of small bowel obstruction.
- Successful surgical management is feasible for this uncommon presentation.

