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Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
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Controlled Fabrication of Bioactive Microfibers for Creating Tissue Constructs Using Microfluidic Techniques.

Yao Cheng1, Yunru Yu1, Fanfan Fu1

  • 1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University , Nanjing 210096, China.

ACS Applied Materials & Interfaces
|January 8, 2016
PubMed
Summary

Researchers developed bioactive microfibers using microfluidics for precise cell placement in tissue engineering. These tunable fibers, enhanced with extracellular matrix (ECM) or GelMA, create complex 3D cellular structures like vessels and scaffolds.

Keywords:
cell-encapsulationhydrogelmicrofibermicrofluidicstissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Microfluidics

Background:

  • Precise control over cell distribution in biocompatible constructs is crucial for tissue engineering.
  • Developing methods for fabricating heterogeneous microstructures with tunable properties is essential.

Purpose of the Study:

  • To generate bioactive microfibers with tunable morphologies, structures, and components for creating diverse tissue constructs.
  • To utilize microfluidics for controlled fabrication of cell-laden microfibers.
  • To enhance microfiber performance in cell culture through bioactive polymer incorporation.

Main Methods:

  • Utilized multibarrel capillary microfluidics with multiple laminar flows for continuous microfiber spinning.
  • Employed immediate gelation of cell-dispersed alginate solutions to form cell-laden alginate microfibers.
  • Incorporated bioactive polymers like extracellular matrix (ECM) or methacrylated gelatin (GelMA) into alginate.

Main Results:

  • Successfully generated cell-laden alginate microfibers with tunable morphologies and structures.
  • Demonstrated improved cell culture performance of microfibers with incorporated bioactive polymers.
  • Created complex three-dimensional (3D) architectural cellular buildings, including biomimetic vessels and scaffolds.

Conclusions:

  • Bioactive microfibers fabricated via microfluidics offer precise control over cellular architecture.
  • Incorporation of ECM or GelMA enhances microfiber functionality for tissue engineering applications.
  • These microfibers provide a versatile platform for constructing complex 3D cellular constructs.