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Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
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Emerging Frontiers in Drug Delivery.
Mark W Tibbitt1,2, James E Dahlman3,4, Robert Langer1,2,5
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, Massachusetts 02142, United States.
Journal of the American Chemical Society
|January 8, 2016
Summary
Effective drug delivery is crucial for therapeutic success, influencing pharmacokinetics and toxicity. Advances in materials science are overcoming barriers in systemic RNA, localized, oral, and biologic drug delivery for improved clinical outcomes.
Area of Science:
- Materials Science
- Pharmacology
- Biotechnology
Background:
- Drug efficacy is determined by administration route, impacting pharmacokinetics, distribution, metabolism, and toxicity.
- Emerging therapeutics like biologics necessitate advanced drug delivery systems for targeted delivery and sustained therapeutic concentrations.
Purpose of the Study:
- To provide a historical overview of drug delivery and controlled release.
- To highlight advancements in four key emerging areas of drug delivery.
- To identify barriers and chemical/materials solutions for clinical impact.
Main Methods:
- Historical review of drug delivery and controlled release principles.
- Analysis of emerging drug delivery fields: systemic RNA, localized therapy, oral, and biologic systems.
- Identification of challenges and material innovations in each area.
Main Results:
- Drug delivery significantly influences therapeutic outcomes and drug behavior in the body.
- Key emerging areas include systemic RNA, localized, oral, and biologic drug delivery.
- Chemical and materials science innovations are crucial for overcoming delivery barriers.
Conclusions:
- Optimized drug delivery systems are essential for maximizing therapeutic benefits and minimizing adverse effects.
- Continued innovation in materials and chemistry is vital for advancing drug delivery technologies.
- Addressing delivery challenges will enable greater clinical impact for novel therapeutics.
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