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Quantitative Scale for the Trifluoromethylthio Cation-Donating Ability of Electrophilic Trifluoromethylthiolating
Man Li, Jinping Guo, Xiao-Song Xue
1Center of Basic Molecular Science, Department of Chemistry, Tsinghua University , Beijing 100084, China.
Abstract:
A new parameter, trifluoromethylthio cation-donating ability (Tt(+)DA), is introduced as a quantitative descriptor for the propensity of electrophilic trifluoromethylthiolating reagents to transfer a CF3S moiety in organic synthesis. The first Tt(+)DA scale of popular reagents has been established through DFT calculations. Excellent correlation has been identified between the Tt(+)DAs of N-SCF3-type reagents and the pKa of the corresponding acids, offering a powerful avenue for the rational design of novel reagents.
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