Low 25-Hydroxyvitamin D Levels in Children with Spina Bifida

Area of Science:

• Pediatrics
• Endocrinology
• Nutritional Science

Background:

• Spina bifida (SB) is a complex congenital condition.
• Vitamin D is crucial for bone health and immune function.
• Children with SB may have unique nutritional needs and risks for vitamin D deficiency.

Purpose of the Study:

• To assess vitamin D status in pediatric patients with spina bifida (SB).
• To identify factors associated with vitamin D levels in this cohort.

Main Methods:

• Retrospective chart review of 38 SB patients at Shriners Hospital for Children, Houston.
• Data collected included demographics, lifestyle factors (screen time, outdoor time, milk/vitamin intake), and serum vitamin D levels.

Main Results:

• 81% of children with SB had insufficient or deficient vitamin D levels (mean 58.8 nmol/L).
• African American and Hispanic descent were associated with lower vitamin D levels (P=0.017).
• Daily vitamin D supplementation correlated with higher vitamin D levels (P=0.046).

Conclusions:

• The majority of children with SB exhibit suboptimal vitamin D levels.
• Even in sunny climates with outdoor activity, deficiency is prevalent.
• Routine vitamin D monitoring and supplementation are advised for children with SB.