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Related Experiment Videos

Hirsutism, its pathogenesis.

M Breckwoldt1, H P Zahradnik, P Wieacker

  • 1Department of Obstetrics and Gynaecology, University of Freiburg, FRG.

Human Reproduction (Oxford, England)
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

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Hirsutism, characterized by male-pattern hair growth in women, stems from increased androgens or heightened follicle sensitivity. Lowered sex hormone-binding globulin (SHBG) increases free androgens, while elevated 5 alpha-reductase activity boosts dihydrotestosterone (DHT) production.

Area of Science:

  • Endocrinology
  • Dermatology

Background:

  • Hirsutism presents as male-pattern hair distribution in females, indicating a virilizing symptom.
  • Its development involves either increased androgen production or enhanced hair follicle sensitivity to androgens.
  • Androgen levels are influenced by ovarian/adrenal secretion, peripheral conversion, and metabolic clearance rates.

Purpose of the Study:

  • To elucidate the complex pathogenesis of hirsutism.
  • To identify key factors contributing to androgen excess and action in hirsutism.
  • To provide a basis for diagnostic and therapeutic strategies in hirsutism.

Main Methods:

  • Analysis of androgen production pathways and their regulation.
  • Assessment of plasma androgen-binding proteins, including sex hormone-binding globulin (SHBG).

Related Experiment Videos

  • Evaluation of the 5 alpha-reductase enzyme activity in hair follicles.

    • Main Results:

    • Decreased plasma SHBG concentrations in hirsutism lead to elevated free androgen levels.
    • Increased intracellular conversion of testosterone to 5 alpha-dihydrotestosterone (DHT) is observed.
    • The 5 alpha-reductase activity in hirsutism patients approaches male levels.

    Conclusions:

    • Hirsutism pathogenesis involves both increased free androgens and heightened follicular sensitivity.
    • Understanding these mechanisms is crucial for effective diagnosis and treatment of hirsutism.
    • Further research is needed to fully elucidate the intricate pathogenesis of hirsutism.