Related Experiment Video
Updated: Mar 27, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Nanonized itraconazole powders for extemporary oral suspensions: Role of formulation components studied by a mixture
Andrea Foglio Bonda1, Maurizio Rinaldi1, Lorena Segale1
1Università degli Studi del Piemonte Orientale "A. Avogadro", Dipartimento di Scienze del Farmaco, Largo Donegani 2/3, 28100 Novara, Italy.
Abstract:
Itraconazole (ITZ) nanocrystal-containing powders were prepared through the combined use of high pressure homogenization (HPH) and spray drying (SD). These powders were intended as base materials for the preparation of extemporary oral suspensions of the drug. The role and the effect of stabilizers on the size of re-dispersed particles were studied using a mixture design and a Scheffé model relating the dried nanosuspension composition to the mean particle diameters. The homogenization process required a surface active agent (Tween 20) to obtain the efficient comminution of itraconazole micronized powder. SD was carried out on ITZ nanosuspensions after addition of a cellulose derivative (Methocel(®) E5) that allowed the prompt re-dispersion of nanoparticles under "in use" conditions. The powders obtained by drying of homogenized systems showed in vitro dissolution profile faster than that of the micronized drug, suggesting a potential ameliorated GI absorption of itraconazole released from the nanosuspensions.
More Related Videos
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Biopharmaceutical Factors Influencing Drug Product Design: Overview

