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Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205
A A Spasov1, K Yu Kalitin2, O Yu Grechko1
1Volgograd State Medical University, Volgograd, Russia.
Abstract:
Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by anticonvulsant activity (by 12 times) and therapeutic index (by 8.5 times). In contrast to sodium valproate, RU-1205 exhibited significant anticonvulsant activity on the model of pentylenetetrazole-induced kindling without tendency to resistance development.
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