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Related Experiment Video

Updated: Mar 27, 2026

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Famous.

Michelle J Kim1, M Tariq Bhatti2, Fiona Costello3

  • 1Department of Ophthalmology, Duke Eye Center, Durham, North Carolina, USA.

Survey of Ophthalmology
|January 9, 2016
PubMed
Summary
This summary is machine-generated.

Fingolimod treatment for multiple sclerosis can cause vision loss due to macular edema. Discontinuation of the drug and topical treatment led to vision recovery and resolution of swelling.

Keywords:
disease-modifying agentsfingolimodmacular edemamultiple sclerosisoptic neuritissphingosine-1-phosphate

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Area of Science:

  • Ophthalmology
  • Neurology
  • Pharmacology

Background:

  • Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Fingolimod is an immunomodulatory drug used to treat relapsing forms of MS.
  • Ocular side effects of fingolimod, including macular edema, are a known concern.

Observation:

  • A 62-year-old female patient with MS developed sudden, painless vision loss in both eyes.
  • Fundus examination and optical coherence tomography confirmed bilateral macular edema.
  • The patient had recently started fingolimod therapy.

Findings:

  • Discontinuation of fingolimod was followed by topical nonsteroidal anti-inflammatory drug and corticosteroid treatment.
  • Complete resolution of macular edema was observed within two months.
  • Visual acuity returned to the patient's baseline levels.

Implications:

  • This case highlights the importance of monitoring for ocular complications in patients treated with fingolimod.
  • Early detection and management, including drug cessation, can lead to favorable visual outcomes.
  • Further research into the mechanisms of fingolimod-induced macular edema is warranted.