Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 27, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

21.0K

Standardizing endpoints in perioperative research.

Oliver Boney1,2, Suneetha R Moonesinghe1,2, Paul S Myles3

  • 1Surgical Outcomes Research Centre, University College Hospital, London, UK.

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|January 9, 2016
PubMed
Summary

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

529
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
529

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating machine learning and pathway modelling to explore factors associated with chronic post-surgical pain and quality of life: a secondary observational analysis of the ENIGMA-II trial.

BJA open·2026
Same author

Systemic corticosteroids for severe community-acquired pneumonia: a narrative review of mechanisms and critical appraisal of recent trials in ICU.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

Prognostic value of the Duke Activity Status Index for preoperative cardiac risk stratification: an international pooled cohort study.

EClinicalMedicine·2026
Same author

Perioperative intravenous fluid and chronic kidney disease: long-term follow-up of the Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (RELIEF) randomised trial.

British journal of anaesthesia·2026
Same author

The effect of intraoperative dexamethasone on glycaemic responses in people with diabetes mellitus: a preplanned analysis of the Perioperative ADministration of Dexamethasone and Infection trial.

British journal of anaesthesia·2026
Same author

Platform trials in anaesthesia and perioperative medicine: a scoping review.

BJA open·2026
Same journal

Comment on: Brachial plexus block at the level of the humeral head: a proof-of-concept observational cadaver and clinical study.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

In reply: Comment on: Brachial plexus block at the level of the humeral head: a proof-of-concept observational cadaver and clinical study.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

Effects of acupoint stimulation for postoperative analgesia after Cesarean delivery: a systematic review and meta-analysis of randomized controlled trials.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

Tracheal ochronosis.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

Association between lactate clearance rate and 28-day mortality in patients with sepsis: a retrospective cohort study and exploration of an optimal lactate clearance as an endpoint of resuscitation.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
Same journal

Lactate clearance in patients with septic shock: identifying the point of diminishing returns.

Canadian journal of anaesthesia = Journal canadien d'anesthesie·2026
See all related articles
This summary is machine-generated.

Standardizing outcome measures in surgery is crucial for high-quality care and research. Consistent, valid endpoints ensure reliable data for comparing treatments and improving patient outcomes.

Area of Science:

  • Perioperative Medicine
  • Clinical Outcomes Research
  • Surgical Innovation

Background:

  • High-quality clinical care and research depend on measuring patient-relevant outcomes.
  • Increasing surgical complexity and patient comorbidities necessitate better understanding of intervention benefits and harms.
  • Effective decision-making, safe care delivery, and quality improvement rely on valid, patient-centered data.

Purpose of the Study:

  • To highlight the critical need for standardized outcome measurement in perioperative research.
  • To emphasize the risks associated with inconsistent and heterogeneous outcome measures.
  • To advocate for collaboration and consensus in defining perioperative endpoints.

Main Methods:

  • The study is a conceptual analysis and synthesis of existing literature on clinical outcomes measurement.

Related Experiment Videos

Last Updated: Mar 27, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

21.0K
  • It reviews the evolution of outcome endpoints beyond traditional mortality and resource use.
  • It discusses the implications of endpoint heterogeneity for research synthesis and clinical decision-making.

    • Main Results:

    • Current perioperative research risks inconsistency due to a lack of standardized, complex outcome measures.
    • Moving beyond simple endpoints (mortality, resource use) to include morbidity, patient-reported outcomes, and functional status is essential.
    • Inconsistent endpoints limit the comparability of trials and the value of meta-analyses.

    Conclusions:

    • Standardization of outcome measurement is fundamental to maximizing the quality and impact of perioperative research.
    • Consensus on complex endpoints is vital to avoid research inconsistencies and ensure meaningful comparisons.
    • Collaborative efforts in standardizing endpoints will enhance the value of research and benefit patients and clinicians.