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Updated: Mar 27, 2026
07:32
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
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[Intrinsic factors, genes, and skin aging]
E Makrantonaki1,2, G P Pfeifer3, C C Zouboulis4
1Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm, Albert-Einstein Allee 23, Life Sciences Building N27, James-Franck Ring/ Meyerhofstr. 11c, 89081, Ulm, Deutschland.
Summary
Skin aging involves genetic and environmental factors impacting skin health. Understanding these mechanisms aids in preventing age-related diseases and extending lifespan.
Area of Science:
- Dermatology and aging research.
- Molecular biology and genetics of skin.
- Epigenetics and skin homeostasis.
Background:
- Skin aging results from intrinsic and extrinsic factors.
- Genetic and epigenetic modifications significantly influence skin aging.
- Understanding aging mechanisms is key to preventing age-related diseases.
Purpose of the Study:
- To summarize new knowledge on genes affecting skin aging.
- To explore biological processes influencing skin homeostasis in old age.
- To connect aging mechanisms with morphological and physiological skin changes.
Main Methods:
- Literature review of recent studies on skin aging.
- Analysis of genetic and epigenetic factors in skin aging.
- Synthesis of information on biological pathways affecting skin.
Main Results:
- Identified key genes and biological processes impacting aged skin.
- Highlighted the role of genetic changes in skin aging.
- Summarized the link between molecular changes and skin characteristics.
Conclusions:
- New insights into skin aging mechanisms are available.
- Understanding these processes can help extend healthy lifespan.
- This knowledge contributes to preventing age-related skin conditions.
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