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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Acute renal infarction: a single center experience.
Paola Mesiano1, Cristiana Rollino2, Giulietta Beltrame2
1Nephrology and Dialysis Unit, San Giovanni Bosco Hospital, Piazza del Donatore di Sangue 3, 10154, Turin, Italy. paola.mesiano@gmail.com.
Journal of Nephrology
|January 9, 2016
Summary
Acute renal infarction is rare, often diagnosed late. Most patients retain stable kidney function after treatment, though one developed end-stage renal disease, highlighting the need for further study on risk factors.
Area of Science:
- Nephrology
- Cardiology
- Radiology
Background:
- Acute renal infarction is an uncommon condition with delayed diagnosis.
- Key risk factors include atrial fibrillation, heart disease, and coagulopathy.
Purpose of the Study:
- To analyze the clinical characteristics, management, and outcomes of patients with acute renal infarction.
- To investigate the evolution of kidney function following acute renal infarction.
Main Methods:
- Retrospective review of 18 patients diagnosed with acute renal infarction via computed tomography (CT).
- Utilized Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy for assessing kidney function and lesions during follow-up.
Main Results:
- Common risk factors identified: hypertension (44%), obesity (33%), atrial fibrillation (28%).
- Flank pain was the primary symptom (72%). Conservative management with anticoagulation (heparin/aspirin) was typical.
- Renal function remained stable in most patients; one progressed to end-stage renal disease requiring hemodialysis.
Conclusions:
- Risk factors for chronic kidney disease post-renal infarction are not well-defined.
- Acute renal infarction generally leads to stable renal function, but long-term outcomes require further investigation.
- Etiology and functional evolution in renal infarction patients warrant additional research.
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