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Overexpression of CSF-1R in nasopharyngeal carcinoma
Li Huang1, Ximing Xu, Yanrong Hao
1Cancer Center, Renmin Hospital of Wuhan University, People's Hospital of Guangxi Autonomous Region, China; whuxxm@yahoo.com, yanronghao.2008@aliyun.com.
Background:
Tumor-associated macrophages play a significant role in tumor progression. CSF-1/CSF-1R is one of the most primary regulators of macrophage physiology in immune system. The expression of CSF-1/CSF-1R in nasopharyngeal carcinoma is unclear.
Objectives:
The aim of this study was to compare the expression of CSF-1R in nasopharyngeal carcinoma to nasopharyngitis for assessing the role CSF-1/CSF-1R in nasopharyngeal carcinoma.
Materials And Methods:
Diagnostic tissues from 56 nasopharyngeal carcinoma patients and 32 nasopharyngitis patients were evaluated retrospectively by immunohistochemical analysis for the expression of CSF-1R.
Results:
Significant differences of CSF-1R expression exists between nasopharyngeal carcinoma patients and nasopharyngitis patients (p<0.001). However, there is no relevance between CSF-1R and worse survival.
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