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Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Related Experiment Video

Updated: Mar 27, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
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Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

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Neoplasms derived from plasmacytoid dendritic cells.

Fabio Facchetti1, Marta Cigognetti1, Simona Fisogni1

  • 1Section of Pathology, Department of Molecular and Translational Medicine, Spedali Civili, University of Brescia, Brescia, Italy.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|January 9, 2016
PubMed
Summary
This summary is machine-generated.

Plasmacytoid dendritic cell neoplasms present as two distinct forms: one linked to myeloid neoplasms with a poor prognosis, and another, blastic plasmacytoid dendritic cell neoplasm, a rapidly progressing leukemia.

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Plasmacytoid dendritic cell neoplasms (PDCNs) are rare hematologic malignancies.
  • PDCNs present in two distinct clinical and pathological forms.

Purpose of the Study:

  • To differentiate and describe the two main forms of PDCNs.
  • To highlight diagnostic criteria and clinical behavior of each PDCN subtype.

Main Methods:

  • Pathological examination of affected tissues (lymph nodes, skin, bone marrow).
  • Immunohistochemistry using plasmacytoid dendritic cell markers.
  • Analysis of clinical data and patient outcomes.
  • Genomic investigation of blastic PDCN.

Main Results:

  • Mature PDCNs are associated with myeloid neoplasms, predominantly affecting males, with a dismal prognosis tied to the myeloid leukemia.
  • Blastic PDCNs exhibit cutaneous and bone marrow tropism, arise from CD4(+)CD56(+) precursors, and progress rapidly.
  • Immunohistochemistry aids in diagnosing blastic PDCNs.
  • Recurrent somatic mutations are identified in blastic PDCNs.

Conclusions:

  • PDCNs comprise two distinct entities with differing clinical trajectories and associations.
  • Blastic PDCN is an aggressive leukemia with potential therapeutic targets identified through genomic studies.