Related Experiment Video

Updated: Mar 27, 2026

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination
11:24

High Precision FRET at Single-molecule Level for Biomolecule Structure Determination

Published on: May 13, 2017

11.4K

Structural Characterizations of the Fas Receptor and the Fas-Associated Protein with Death Domain Interactions

Urmi Roy1

  • 1Department of Chemistry and Biomolecular Science, and Center for Advanced Materials Processing, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699-5665, USA. urmi@clarkson.edu.

The Protein Journal
|January 9, 2016
PubMed

Insights

This study explores the structural details of Fas receptor and Fas-associated protein with death domain (FADD) interactions, crucial for initiating programmed cell death. Computational analysis reveals key aspects of their death domain binding.

Area of Science:

  • Cell biology
  • Molecular biology
  • Biochemistry

Background:

  • The Fas receptor is a key death receptor involved in apoptosis.
  • Fas-associated protein with death domain (FADD) is essential for Fas receptor signaling.
  • Fas-FADD interactions trigger caspase cascades, leading to programmed cell death.

Purpose of the Study:

  • To computationally investigate the structural features of Fas and FADD death domains.
  • To analyze the interfacial interactions between Fas and FADD.

Main Methods:

  • Computational approach utilized.
  • Exploration of structural aspects of death domains.
  • Analysis of interfacial binding.

Main Results:

  • Identified essential structural elements governing Fas-FADD interactions.
  • Characterized the binding interface critical for signal transduction.
  • Provided insights into the molecular mechanisms of apoptosis induction.

Conclusions:

  • The study elucidates critical structural determinants of Fas-FADD interactions.
  • Understanding these interactions is vital for comprehending apoptosis regulation.
  • Computational methods offer valuable insights into molecular interactions in cell death pathways.
Keywords:
Death domainFasFas-associated protein with death domainImmunologyStructural biology

More Related Videos

Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques08:28

Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques

Published on: November 2, 2018

8.9K
Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell14:09

Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell

Published on: August 4, 2015

13.1K

Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.8K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
7.1K
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
3.4K