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Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Altered functional connectivity in persistent developmental stuttering.

Yang Yang1,2,3, Fanlu Jia1,2,3, Wai Ting Siok2,4

  • 1Neuroimaging Laboratory, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, China.

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|January 9, 2016
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Summary
This summary is machine-generated.

Resting-state brain imaging reveals altered functional connectivity in the cerebellum and basal ganglia in adults with persistent developmental stuttering (PDS). These neural differences correlate with stuttering severity, offering potential biomarkers for this speech disorder.

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Area of Science:

  • Neuroscience
  • Speech-language pathology
  • Functional neuroimaging

Background:

  • Persistent developmental stuttering (PDS) is a complex speech disorder with unknown origins.
  • Previous studies suggest basal ganglia and cerebellar involvement but are limited by task-related confounds.
  • Resting-state functional magnetic resonance imaging (fMRI) offers a way to study brain networks without task performance variability.

Purpose of the Study:

  • To investigate resting-state functional connectivity in cerebellar-cortical and basal ganglia-thalamocortical networks in adults who stutter.
  • To identify neural differences between individuals with PDS and fluent controls.
  • To explore the relationship between functional connectivity and stuttering severity.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) was employed.
  • 16 adults who stutter and 18 age-matched fluent speakers participated.
  • Seed-to-voxel analysis was used to examine functional connectivity within specific brain networks.

Main Results:

  • Adults who stutter exhibited altered cerebellar connectivity to the motor cortex and within cerebellar regions.
  • Cerebellar functional connectivity correlated significantly with stuttering severity.
  • Reduced connectivity was observed between the putamen and the superior temporal gyrus/inferior parietal lobules in adults who stutter.

Conclusions:

  • Abnormal resting-state functional connectivity in the cerebellum and basal ganglia-thalamocortical circuits is associated with persistent developmental stuttering.
  • These neural alterations may impact language planning and motor execution necessary for fluent speech.
  • Findings provide potential neurobiological insights and biomarkers for PDS.