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Updated: Mar 27, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Developmental venous anomaly, capillary telangiectasia, cavernous malformation, and arteriovenous malformation:
M Yashar S Kalani1, Joseph M Zabramski1, Nikolay L Martirosyan1
1Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Abstract:
Vascular malformations of the central nervous system are thought to originate from abnormal developmental processes during embryogenesis. Reports have cited the dynamic nature of these lesions and their "maturation" into other types of malformations. Herein we report on three patients with vascular malformations who exhibited dynamic alterations with stepwise progression of their lesions. These cases lend support to the hypothesis that these malformations may constitute the spectrum of a single disease caused by alterations in a common developmental program and that accumulating injury (e.g., by radiation) may allow one malformation type to mature into another. This concept warrants further investigation.
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