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Related Experiment Video

Updated: Jul 12, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Experimental corneal studies with the excimer laser.

D M Taylor, F A L'Esperance, J W Warner

    Journal of Cataract and Refractive Surgery
    |July 1, 1989
    PubMed
    Summary

    Excimer laser treatments precisely reshape the cornea. While initial healing shows mild haze in humans and primates, further research is needed to understand its effect on vision.

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    Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2014

    Area of Science:

    • Ophthalmology
    • Biomedical Engineering
    • Laser Technology

    Background:

    • Excimer lasers offer precise tissue ablation.
    • Wide-area central corneal reprofiling is a potential application.
    • Limited penetration minimizes damage to adjacent tissues.

    Purpose of the Study:

    • To describe a beam-modifying system for corneal reprofiling.
    • To evaluate the initial clinical outcomes and histologic findings in primates and humans.

    Main Methods:

    • Development of a specialized beam-modifying system.
    • Clinical studies involving non-human primates.
    • Clinical studies involving ten human patients with blind eyes.
    • Long-term data collection and interim histologic analysis.

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    Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
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    Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss

    Published on: April 24, 2020

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    Last Updated: Jul 12, 2026

    Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
    07:29

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    Published on: November 12, 2015

    Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
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    Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

    Published on: February 15, 2019

    Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
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    Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss

    Published on: April 24, 2020

    Main Results:

    • Ablated corneal tissue in humans and primates exhibited normal healing responses.
    • A mild to moderate stromal interface haze was observed post-ablation.
    • Some early loss of refractive effect was noted, followed by stabilization.

    Conclusions:

    • Excimer laser corneal reprofiling demonstrates a normal healing pattern.
    • The impact of stromal haze on best-corrected vision requires further investigation.
    • Early refractive changes appear to stabilize during the healing process.