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Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
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Integration of HIV infant testing into immunization programmes: a systematic review.

Dick Chamla1, Chewe Luo, Georgette Adjorlolo-Johnson

  • 1Paediatric HIV, Health Section.

Paediatrics and International Child Health
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Summary

Integrating HIV infant testing into immunization sessions is acceptable and feasible for early infant diagnosis. However, further research is needed to understand the impact on vaccination uptake.

Keywords:
HIV infant testingImmunizationIntegration

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Area of Science:

  • Public Health
  • Pediatrics
  • Infectious Diseases

Background:

  • Integrating HIV infant testing into immunization sessions aims to improve early infant diagnosis coverage.
  • This strategy seeks to enhance access to timely HIV testing for infants.

Purpose of the Study:

  • To systematically review the evidence on the outcomes of integrating HIV infant testing into immunization sessions.
  • To assess the feasibility, acceptability, and impact of this integrated service delivery model.

Main Methods:

  • A systematic review of peer-reviewed and grey literature (2002-2013) was conducted.
  • Searched electronic databases (MEDLINE, Google Scholar) and institutional reports.
  • Included randomized controlled trials, observational, and qualitative studies; meta-analysis was not feasible due to heterogeneity.

Main Results:

  • Nine articles met inclusion criteria; none were randomized controlled trials.
  • Maternal acceptability of infant HIV testing during immunization visits ranged from 89.5% to 100%.
  • Return rates for HIV test results varied (56.8%-86.0%); increased HIV testing uptake was observed. One study noted stable/increased urban vaccination uptake but decreased rural uptake. Perceived stigma was a potential risk.

Conclusions:

  • HIV testing during immunization visits is an acceptable and feasible service delivery model.
  • The impact of this integration on vaccination uptake requires further investigation.
  • More research, particularly randomized controlled trials, is needed to confirm efficacy and address potential risks like stigma.