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Genetic effects on source level evoked and induced oscillatory brain responses in a visual oddball task
Marios Antonakakis1, Michalis Zervakis1, Catharina E M van Beijsterveldt2
1School of Electronic and Computer Engineering, Technical University of Crete, Chania 73100, Greece.
Biological Psychology
|January 9, 2016
Summary
Induced brain oscillations, a measure of brain activity, are heritable traits. This finding suggests that phase-independent oscillatory responses could be valuable endophenotypes for understanding psychiatric genetics.
Area of Science:
- Neuroscience
- Behavioral Genetics
- Psychiatric Genetics
Background:
- Oddball tasks elicit brain potential and oscillatory activity.
- These responses are considered heritable and potential endophenotypes for clinical conditions.
- Both phase-locked (evoked) and phase-independent (induced) oscillatory responses occur.
Purpose of the Study:
- To investigate the heritability of phase-locked and phase-independent oscillatory responses.
- To determine if these oscillatory responses can serve as endophenotypes in psychiatric genetics.
Main Methods:
- EEG recordings from 213 twin pairs (monozygotic and dizygotic).
- Participants performed a visual oddball task.
- Group Independent Component Analysis (group-ICA) and time-frequency decomposition were used to analyze oscillatory responses.
Main Results:
- Induced (phase-independent) oscillatory responses exhibited the highest heritability (24-55%).
- Evoked (phase-locked) oscillatory responses and spectral energy showed lower heritability (1-35.6% and 4.5-32.3%, respectively).
Conclusions:
- Phase-independent induced oscillatory responses are highly heritable.
- These responses encode distinct functional aspects of brain activity compared to evoked responses.
- Modulation of ongoing oscillatory activity may serve as an additional endophenotype for behavioral and psychiatric genetics.
