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Updated: Mar 27, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

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IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.

Gavin D Brooks1, Louise McLeod1, Sultan Alhayyani1

  • 1Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, Clayton, Victoria, Australia.

Cancer Research
|January 9, 2016
PubMed
Summary

Interleukin-6 (IL6) trans-signaling drives KRAS-mutant lung adenocarcinoma. Blocking IL6 trans-signaling, a key pathway, suppressed tumor growth in mice and may offer a new therapeutic target for lung cancer.

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